International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 7 | Case Report | Open Access DOI

Sensorineural Deafness and Facial Palsy: A Rare Presentation of Granulomatosis with Polyangiitis in a Saudi Patient – Case Report with Review

Fatima S. Alangari^*

Fatima Saad Alangari 1*, Alhassan Jaban Algazlan2, Mariam Saleh Alamro3, Sultan Mogren Almogairen4

1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia

2Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia

3Department of Otolaryngology-Head and Neck Surgery, King Abdullah Ear Specialist Center (KAESC), College of Medicine, King Saud University, Riyadh

4Professor and Consultant of Rheumatology, Department of Medicine, King Saud University, Riyadh, Saudi Arabia

^*Correspondence to: Fatima S. Alangari 

Abstract

Granulomatosis with polyangiitis (GPA) is a rare autoimmune vasculitis typically affecting the respiratory tract and kidneys. This case report describes a 33-year-old Saudi female presenting with persistent otitis media, progressive hearing loss, and facial nerve paralysis unresponsive to conventional treatment. She later developed systemic symptoms, including oral ulcers, gastrointestinal bleeding, and a cecal mass. Histopathological analysis of the middle ear and cecal tissue confirmed GPA, despite the absence of renal or pulmonary involvement. Serology revealed elevated PR3 antibodies. The patient showed marked improvement following immunosuppressive therapy with steroids and rituximab. This case underscores the need to consider GPA in patients with atypical, treatment-resistant otologic symptoms and highlights the importance of early recognition and multidisciplinary management to prevent irreversible complications.

Keywords:

Wegener’s granulomatosis; Granulomatosis with polyangiitis; Otitis media; Facial nerve palsy; Oral ulcer

Citation:

Fatima Saad Alangari, Alhassan Jaban Algazlan, Mariam Saleh Alamro, Sultan Mogren Almogairen. Sensorineural Deafness and Facial Palsy: A Rare Presentation of Granulomatosis with Polyangiitis in a Saudi Patient – Case Report With Review. Int Clinc Med Case Rep Jour. 2025;4(7):1-16.