International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 10 | Case Report | Open Access DOI

Severe Insulin Resistance secondary to insulin antibodies induced by Insulin Glargine

Dr. Tariq Tabbakh^*

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia

^*Correspondence to: Dr. Tariq Tabbakh 

Abstract

Background: Medical literature well-documents insulin resistance related to insulin antibodies (IAs), particularly in patients treated with human insulin or insulin analogs.

Case report: We report a case involving a 25-year-old female patient with a 7-year history of type 1 diabetes mellitus (DM) who required hospital admission due to a poorly controlled glycemic state (HbA1C 10.0%) despite escalating insulin dosages, reaching four units per kilogram per day before admission and concomitant progressive weight loss. The presence of circulating anti-insulin antibodies was identified upon investigation, leading to severe insulin resistance. The patient responded positively to the replacement of insulin glargine with insulin detemir.

Conclusion: This case highlights the importance of recognizing immunological factors, specifically anti-insulin antibodies, as potential contributors to insulin resistance in individuals with type 1 diabetes mellitus.

Keywords:

Diabetes mellitus; Detemir; Insulin dosage; Glargine

Citation:

Tabbakh T. Severe Insulin Resistance secondary to insulin antibodies induced by Insulin Glargine. Int Clinc Med Case Rep Jour. 2024;3(10):1-12.