International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 1, Issue 4 | Case Report | Open Access

Takayasu Arteritis: An Exceptionally Advanced Clinical Presentation

Muhammad Haseeb ul Rasool*

King Edward Medical University, Lahore, Pakistan

*Correspondence to: Muhammad Haseeb ul Rasool 

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Takayasu Arteritis (TKA) is granulomatous inflammation of the proximal aorta and its main branches, characterized by granulomatous inflammation. As compared to Giant Cell Arteritis (GCA), diagnosis of TKA is a clinical challenge owing to vague initial symptoms and impossibility to biopsy major vessels, therefore, clinical and radiological parameters are the main diagnostic standards. Ishikawa’s guidelines were the first clinical guideline regarding the diagnosis of TKA, however, guidelines by the American College of Rheumatology are the mainstay of clinical diagnosis. The development of TKA has been associated with Mycobacterium tuberculosis infection and with rheumatic fever in case series, but the exact trigger factor is unknown to the best of our knowledge. Damage caused by TKA is irreversible due to ischemic changes, therefore active disease status, and end-organ damage presenting as renal artery stenosis, severe hypertension, and shrunken kidneys are the poor prognostic factors. TKA is the most common cause of non- atherosclerotic vascular stenosis. We present a case of a young female, who presented at 16 years of age with involvement of ascending and descending aorta that required coronary artery bypass grafting at age of 17 and later on required Percutaneous Coronary Stenting to Left Main Stem too. Due to worsening hypertension and shrinking kidneys, she required renal artery stenting. In the course of progression, she developed radial artery and carotid artery stenosis, however, the disease progress started to halt, once she was started on glucocorticoids.


Takayasu Arteritis (TKA); Giant Cell Arteritis (GCA); Hypertension; Cardiology


Muhammad Haseeb ul Rasool, Rizwan Raheem.Takayasu Arteritis: An Exceptionally Advanced Clinical Presentation.Int Clinc Med Case Rep Jour. 2022;1(4):1-6.