International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 5, Issue 6 | Case Report | Open Access
Gábor Somlyai*
Beáta Zs Kovács1, Ildikó Somlyai1, András Papp2, Gábor Somlyai1*
1HYD LLC for Cancer Research and Drug Development, Budapest, Hungary
2Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary
*Correspondence to: Gábor Somlyai
Fulltext PDFDiffuse astrocytomas (WHO grade II) are slow-growing yet ultimately progressive primary brain tumors with a substantial risk of malignant transformation. When surgical resection is not feasible, long-term observation becomes a key component of clinical management. In this context, deuterium-depleted water (DDW) has been proposed as a potential adjunctive therapeutic strategy. We present the case of a 34-year-old female patient, diagnosed in 2005 with a supratentorial diffuse astrocytoma following the development of right-sided neurological deficits and seizure activity. Neuroimaging demonstrated a large, irregular lesion suggestive of early anaplastic transformation; however, histopathological analysis confirmed a WHO grade II astrocytoma. Given the tumor’s location, surgical resection was not feasible, and the patient was managed conservatively with radio- and chemotherapy and long-term clinical and radiological monitoring. The patient had 4 courses of DDW treatment in 4 years. Follow-up of the patient’s condition demonstrated that deuterium depletion counteracted the growth of the tumor. The data also revealed that an early break in DDW consumption promoted progression of the disease, as confirmed by MRI scan. This study confirms that deuterium depletion is an effective adjuvant therapy when used alone and prolongs life when conventional treatments have been exhausted.
Astrocytoma; Hemiparesis; Deuterium (D); Deuterium-depleted water (DDW); Radiotherapy; Chemotherapy; Case study
Beáta Zs Kovács, Ildikó Somlyai, András Papp, Gábor Somlyai. The Effect of Deuterium-Depleted Water on the Quality of Life and Lifespan of an Astrocytoma Patient. Int Clinc Med Case Rep Jour. 2026;5(6):1-11.