International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 1 | Case Report | Open Access DOI
Carly Hubers*
Meumbur Praise Kpughur-Tule1, Carly Hubers2*, Dinakaren Umashankar1, Aaron Palinkas1, Ngumimi Peace Kpughur-Tule1, Mohammad Khan1, Kendall Conway2, Alexander M. Satei3
1Department of Internal Medicine, Wayne State University/Trinity Health Oakland, Pontiac, MI
2Wayne State University School of Medicine, Detroit, MI
3Department of Radiology, Wayne State University/Trinity Health Oakland, Pontiac, MI
*Correspondence to: Carly Hubers
Fulltext PDFCardiac amyloidosis typically manifests as restrictive cardiomyopathy, but this case presents an unusual overlap of heart failure with reduced ejection fraction, sustained ventricular tachycardia, and severe coronary artery disease in a largely asymptomatic patient. A 77-year-old male with Agent Orange exposure and a history of recurrent premature ventricular contractions experienced syncope, leading to the diagnosis through multimodal imaging and amyloid workup. The coexistence of infiltrative and ischemic pathology complicated management. This case notes the diagnostic challenges in differentiating cardiac amyloidosis from ischemic cardiomyopathy and highlights the potential role of environmental exposures in disease pathogenesis. Recognition of such atypical presentations is crucial for optimizing diagnostic and therapeutic strategies.
Meumbur Praise Kpughur-Tule, Carly Hubers, Dinakaren Umashankar, Aaron Palinkas, Ngumimi Peace Kpughur-Tule, et al. Unusual Presentation of Cardiac Amyloidosis in a Vietnam Veteran with Agent Orange Exposure. Int Clinc Med Case Rep Jour. 2025;4(2):1-3.