International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is a life-threatening acute abdominal disorder characterized by inflammatory injury and intestinal barrier dysfunction. β-Catenin, a core mediator of the Wnt pathway, regulates inflammation, epithelial proliferation, and tissue repair—key processes in appendicitis pathogenesis.
Objective: To synthesize basic experimental evidence on β-Catenin’s role in appendicitis and explore its relevance to nursing practice.
Methods: A retrospective analysis of PubMed (2018–2024) using keywords “Appendicitis[MeSH] AND β-Catenin[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models investigating β-Catenin in appendicitis.
Results: Ten studies were included. β-Catenin activation (nuclear translocation, upregulated expression) was observed in appendiceal tissues of animal models (mouse/rat) and LPS-stimulated intestinal epithelial cells, correlating with reduced pro-inflammatory cytokines (TNF-α, IL-6) and enhanced epithelial barrier repair. β-Catenin activation (via LiCl/Wnt3a) alleviated appendiceal damage.
Conclusion: β-Catenin modulates inflammation and tissue repair in appendicitis. Basic findings support nursing strategies for infection prevention and recovery promotion.
Appendicitis; β-Catenin; Inflammation; Tissue repair
Chen W. β-Catenin Signaling in Appendicitis: A Retrospective Analysis of Basic Experimental Studies and Nursing Implications. Int Clinc Med Case Rep Jour. 2025;4(11):1-5.