International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is an acute inflammatory disorder driven by leukocyte infiltration and vascular dysfunction, and vascular cell adhesion molecule-1 (VCAM-1)—a key adhesion molecule—mediates leukocyte recruitment and amplifies inflammatory responses.
Objective: To synthesize basic experimental evidence on VCAM-1’s role in appendicitis and explore its nursing relevance.
Methods: Retrospective analysis of PubMed (2019–2024) using keywords “Appendicitis[MeSH] AND VCAM-1[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models focusing on VCAM-1 in appendicitis.
Results: Eleven studies were included. VCAM-1 expression was upregulated in appendiceal vascular endothelium of animal models (mouse/rat) and LPS-stimulated endothelial cells, correlating with increased leukocyte infiltration and vascular permeability. VCAM-1 inhibition alleviated appendiceal inflammation and tissue damage.
Conclusion: VCAM-1 is critical for inflammatory progression in appendicitis, providing a molecular basis for nursing strategies in inflammation monitoring and infection prevention.
Appendicitis; Endothelial cells; Vascular permeability; Leukocyte infiltration
Chen W. VCAM-1Analysis of Basic Experimental Studies and Nursing Implication. Int Clinc Med Case Rep Jour. 2025;4(11):1-5.