International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 5, Issue 7 | Case Report | Open Access
Saqib Ahmed*
Sheenam Azad1, Saqib Ahmed2*, Anita Jaiswal3
Professor, Assistant Professor, Junior Resident
Department of Pathology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India
*Correspondence to: Saqib Ahmed
Fulltext PDFWater-clear cell parathyroid adenoma (WCCA) is an exceptionally rare histological variant of parathyroid adenoma, representing less than 1% of cases. It is composed of cells with abundant glycogen-rich clear cytoplasm and often poses a diagnostic dilemma due to its resemblance to metastatic clear-cell neoplasms. We present a case of a 61-year-old male with end-stage renal disease and tertiary hyperparathyroidism. Imaging revealed a lesion posterior to the left thyroid lobe. Histopathological examination demonstrated sheets of clear cells with distinct borders and hyperchromatic nuclei, consistent with WCCA. Careful exclusion of other clear-cell tumors was essential for diagnosis. Awareness of this entity is crucial to avoid misdiagnosis and ensure appropriate clinical management.
Sheenam Azad, Saqib Ahmed, Anita Jaiswal. Water-Clear Cell Parathyroid Adenoma: A Rare Entity in Tertiary Hyperparathyroidism. Int Clinc Med Case Rep Jour. 2026;5(7):1-3.