Annals of Otolaryngology Head and Neck Surgery (ISSN 2835-7132) | Volume 5, Issue 5 | Short Opinion | Open Access DOI
Ioannis Chatzistefanou*
Ioannis Chatzistefanou*, Martha Pyraki, Vassilis Petsinis
Oral and Maxillofacial Surgery, Attikon General Univerity Hospital, Athens Medical School, Greece
*Correspondence to: Ioannis Chatzistefanou
Fulltext PDFMetastatic cervical cancer of unknown primary (MCCUP) constitutes a challenging clinical entity for head and neck surgeons, which represents 3-5% of the total head and neck squamous cell carcinomas and 2-10% of the cases that proceed with palpable cervical lymph nodes. Usually, older male patients present with an asymptomatic, progressively enlarging neck mass, usually near the jugulodigastric lymph nodes. Despite the advancement of diagnostic modalities, such as PET/CT, endoscopy, US-FNAc, and biomarkers, some patients still have occult primary cancer with a controversial clinical management algorithm that is usually based on risk stratification. Early-stage disease is confronted with a single-modality treatment, preferably surgery, due to the staging potential, while advanced stages often require chemoradiation. The MCCUP treatment algorithm may shift toward precision medicine in the future, which offers accurate and individualized therapeutic outcomes.
Oral cancer, neck dissection, unknown primary, neck metastasis, occult metastasis
Ioannis Chatzistefanou, Martha Pyraki, Vassilis Petsinis. Clinical Management of Metastatic Cervical Cancer of Unknown Primary. Annal of Otol Head and Neck Surg. 2026;5(5):1-3.