Annals of Otolaryngology Head and Neck Surgery (ISSN 2835-7132) | Volume 4, Issue 6 | Case Report | Open Access
Cárita Lopes Macêdo*
Cárita Lopes Macêdo1*, Jordanna Lousek1, Rogério Pezato2, Wilder Alves1, Claudiney Candido Costa1, Hugo Valter Lisboa Ramos1, Leandro Castro Velasco1
1Centro Estadual de Reabilitação e Readaptação Dr. Henrique Santillo, CRER, Goiânia, Goiás, Brazil
2Universidade Federal de São Paulo – UNIFESP, São Paulo, São Paulo, Brazil
*Correspondence to: Cárita Lopes Macêdo
Fulltext PDFAim: To assess the impact of systemic corticosteroid and antibiotic therapy on tissue eosinophilia in nasal polyps of patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Methods: This prospective cohort study included adult patients with CRSwNP undergoing endoscopic sinus surgery (ESS) between May 2023 and September 2024 at the Centro de Reabilitação e Readaptação Dr. Henrique Santillo (CRER), Goiânia, Brazil. A nasal polyp biopsy was performed seven days before surgery, after which patients were prescribed oral prednisone and amoxicillin–clavulanate. During ESS, additional polyp fragments were collected for histopathological evaluation. All analyses were performed by experienced pathologists blinded to the timing of sample collection, with eosinophilic inflammation defined as >10 eosinophils/HPF.
Results: The study included 22 patients. The number of tissue eosinophils was significantly lower in intraoperative samples following the use of corticosteroids and antibiotics.
Conclusion: Systemic corticosteroid and antibiotic therapy prior to surgery, while improving operative conditions, may confound the histopathological classification of CRSwNP, with implications for prognosis and the use of biologics targeting type 2 inflammation.
Chronic Rhinosinusitis; Nasal Polyps; Corticosteroids; Antibiotics
Cárita Lopes Macêdo, Jordanna Lousek, Rogério Pezato, Wilder Alves, Claudiney Candido Costa, Hugo Valter Lisboa Ramos, et al. Impact of Systemic Corticosteroid and Antibiotic Use on Tissue Eosinophilia in Nasal Polyps of Patients with Chronic Rhinosinusitis. Annal of Otol Head and Neck Surg. 2025;4(6):1-6.