Annals of Otolaryngology Head and Neck Surgery (ISSN 2835-7132) | Volume 2, Issue 1 | Research Article | Open Access

Surgery Remains the Best Treatment for Floor of Mouth Squamous Cell Carcinoma

Janet R Williams*

Department of Radiation Oncology, The Prince of Wales Cancer Centre, High St, Randwick, Australia

*Correspondence to: Janet R Williams 

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Aims: This review seeks to define if radiotherapy is comparable to surgery in eradicating Floor of Mouth (FOM) carcinomas.

Materials and Methods: This ethics approved study-audited information on patients with a FOM squamous cell carcinoma. Data was sourced from the electronic medical record (EMR) system (MOSAIQ) for each patient, hospital notes, and referral correspondence. Analysis was performed using Pearson Chi-square or Fisher’s Exact Test. The Kaplan-Meier method described time-to-event data, with the log rank test used to assess differences between curves. Endpoints were local/ultimate local control, overall/cancer-specific survival, and time-to-development of second malignancy.

Results: Eligible were 184 patients. The majority were males with a smoking history. Surgery was used in 150 (82%) patients, with 32 treated with radiotherapy alone. There was no difference in patient and disease factors between the two populations. Five-year ultimate local control for patients treated with radiotherapy alone was 46% versus 84% for surgery alone, and 68% when combined with radiotherapy (p=0.001). There was a high likelihood of developing a second malignancy. A new primary was evident in 53 (29%) patients, with a median time to development of 4.4 years.

Conclusions: Surgery is a superior modality to radiotherapy alone to address FOM carcinoma.


Head and neck cancer; Floor of mouth; Carcinoma; Surgery; Radiotherapy; Recurrence


Robert I Smee, Janet R Williams, Damian P Kotevski.Surgery Remains the Best Treatment for Floor of Mouth Squamous Cell Carcinoma. Annal of Otol Head and Neck Surg. 2023;2(1):1-15.