Annals of Otolaryngology Head and Neck Surgery (ISSN 2835-7132) | Volume 1, Issue 1 | Research Article | Open Access
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Japan
*Correspondence to: Akira HaraFulltext PDF
Adenoid Cystic Carcinoma (ACC) is a rare tumor that grows slowly but often causes distant metastases. The most common site of occurrence is salivary glands, but it can also occur in External Auditory Canal (EAC). There are some reports that MYB Immunohistochemistry (IHC) is useful for the diagnosis of ACC, but there are no reports of ACC arising in EAC diagnosed by MYB IHC. In this study, the usefulness of MYB IHC for the diagnosis of ACC arising in EAC was examined. Four cases of ACC arising in EAC were identified at Gifu University hospital from 2004 to 2021. IHC including MYB was performed on these cases. Then, the staining intensity of MYB was scored based on the previous report. Three of the four cases were positive for MYB IHC. One case was scored “0” and three cases were diagnosed to have a score of “2”. S-100, α-SMA, AE1/AE3 and c-kit were positive staining in all cases, and CEA was negative staining in all cases. MYB IHC was performed on 4 cases of ACC arising in EAC. Three of the four cases were positive for MYB IHC and its utility was confirmed.
Adenoid cystic carcinoma; External auditory canal tumor; Ear canal; MYB; MYB-NFIB; Immunohistochemistry
Masashi Kuroki, Akira Hara, Hirofumi Shibata, Toshimitsu Ohashi, Kazuhiro Kobayashi, Natsuko Suzui, et al.The Diagnostic Utility of MYB Immunohistochemistry for Adenoid Cystic Carcinoma Arising In External Auditory Canal. Annal of Otol Head and Neck Surg. 2022;1(1):1-7.